Thursday, September 26, 2013

Case Studies

The effects of meditation on the brain.
-          Aim: Examine differences in brain activity that might have resulted from having engaged in meditation over a long period of time.
-          Participants: -12 experienced meditators 7/12 were Asian.
                        - Untrained Caucasian that was interested in trying to learn meditation.
                        - Control group
-          Procedure: The participant’s brains were scanned using fMRI while they concentrated on a red dot on a screen in front of them, and while at rest with no concentration. Researchers played various noises in an attempt to distract participants from meditation.
-          Results: During meditation, attention related networks in the brain and the visual cortex would be more active, than during rest periods. Novice meditators found it more difficult than experts to sustain their concentration. Experienced meditators showed a response to the disturbing stimuli, not in terms of a change in attention away from the target of their concentration meditation, but in terms of some kind of adjustment of concentration, perhaps an active resistance to being disrupted.
-          Conclusion: The experienced meditators showed response to the disturbing stimuli, not in terms of a change in attention away from the target of their concentration meditation, but in terms of some kind of adjustment of concentration, perhaps an active resistance to being disrupted. The differences are probably due to neuroplasticity, some kind of changes in the brain that have occurred over time as a result of periods of sustained meditation.
Changes in the brain after juggling training.
-          Aim: Determine whether both functional and structural changes could be detected in the human brain as a result of learning a new motor skill.
-          Participants: - 21 females
                        -  3 males
-          Procedure: Half of the participants had 3 months to learn a basic juggling routine. Structural MRI scans were done before and after the three months, and a third scan was made 3 months later. During this time participants did not practice their skills.
-          Result: While there was no significant group differences in brain structure in the first scan (before training), two areas of the brain were significantly different in size after training. The difference became smaller in the third scan, when practice had ceased for three months. These differences were apparently due to an increase in volume in the two regions of the juggler’s brain.  
-          Conclusion: The practice of watching balls moving through the air repetitively and learning to move in response to this strengthened the connections between neurons in the parts of the brain responsible for this activity.

Changes in the brains of experienced London taxi drivers.
-          Aim: Determine if fully London Taxi drivers have structural differences in their hippocampi as a result of being “on the knowledge”
-           Participants: Fully licensed London Taxi drivers, with a range of experience years.
                        
-          Procedure:  The researchers used MRI scans of the brains of the Taxi drivers and compared them to scans of healthy males who did not drive Taxis.

-          Result: Researchers found that both the left and right hippocampi were significantly higher in volume in the brains of the Taxi drivers, although there were some parts of the Hippocampi that were smaller in the brain of Taxi drivers. He researchers found a positive correlation that could not be accounted for by age differences.

-           Conclusion: There has probably been a redistribution of grey matter in the hippocampi as a result of intense development and use of spatial memory skills, specifically those relating to learning and remembering routes through the city.


PET evaluation of bilingual language compensation following early childhood brain damage.
-          Aim: Can the fact that both of your parents are deaf and that you have to use sign language from a young age, can this might have had something to do with his ability to speak despite brain damage.

-          Participants: Subject “MA” who suffered a lesion on the left frontal lobe at the age of 6 weeks.              

                        -  12 control subjects who were fluent in sign language.

-          Procedure: The researchers compared MA and 12 other control patients, using PET scan they compared them while the participants produced narrative speech or signs. The participants also had to do perform a set of motor control tasks.

-          Result: The researchers found that MA’s right hemisphere was more active than control subjects’ during the production of both speech and sign language. MA seemed more anxious and agitated. He was judged normal by independent observers of speech and sign language production and neuropsychological tests. These findings suggest that language function seems to have developed in the right hemisphere instead of the left hemisphere as a form as adaption.


-          Conclusion: MA’s language abilities may have developed in the right hemisphere at the expense of visuo-spatial ability.